There is limited information to guide management of people with NOAC overdose with and without bleeding.
Information should be collected on the ingested dose and time of ingestion.
If rivaroxaban overdose is suspected, the use of activated charcoal up to 8 hours after overdose to reduce absorption may be considered.
Due to its low solubility, rivaroxaban absorption plateaus at doses of 50 mg and above, thus limiting exposure in the majority of subjects.
In case of overdose, the patient should be observed carefully for bleeding complications or other adverse reactions.