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<p class=MsoNormal><a name="_MailOriginal"><o:p>&nbsp;</o:p></a></p>

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              <p class=MsoNormal align=center style='text-align:center;
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              style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;
              color:#757575'>Issue 1 &nbsp; |&nbsp; 16&nbsp;February 2021&nbsp;<o:p></o:p></span></span></p>
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              <span style='mso-bookmark:_MailOriginal'></span>
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            <span style='mso-bookmark:_MailOriginal'></span>
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          <span style='mso-bookmark:_MailOriginal'></span></td>
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            -ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%'>
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              <td style='padding:6.75pt 13.5pt 6.75pt 13.5pt;-ms-text-size-adjust: 100%;
              -webkit-text-size-adjust: 100%'>
              <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0
               width="100%" style='width:100.0%;background:#55B3D8;border-collapse:
               collapse;mso-yfti-tbllook:1184;mso-padding-alt:0cm 0cm 0cm 0cm;
               min-width: 100%;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%'>
               <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:
                yes'>
                <td valign=top style='padding:13.5pt 13.5pt 13.5pt 13.5pt'>
                <p class=MsoNormal align=center style='text-align:center;
                line-height:150%'><span style='mso-bookmark:_MailOriginal'><strong><span
                style='font-size:13.5pt;line-height:150%;font-family:"Helvetica",sans-serif;
                color:#F2F2F2'>Study Overview </span></strong></span><span
                style='mso-bookmark:_MailOriginal'><span style='font-size:10.5pt;
                line-height:150%;font-family:"Helvetica",sans-serif;color:#F2F2F2'><br>
                </span></span><span style='mso-bookmark:_MailOriginal'><span
                style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;
                color:#F2F2F2'>The TRACK trial will evaluate whether a small dose
                of rivaroxaban, a blood-thinning medication, would reduce
                cardiovascular death or major cardiovascular events in patients
                with advanced stages of chronic kidney disease.</span></span><span
                style='mso-bookmark:_MailOriginal'><span style='font-size:10.5pt;
                line-height:150%;font-family:"Helvetica",sans-serif;color:#F2F2F2'>
                <o:p></o:p></span></span></p>
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             </tr>
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            <span style='mso-bookmark:_MailOriginal'></span>
           </tr>
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          <span style='mso-bookmark:_MailOriginal'></span>
         </tr>
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          <td valign=top style='padding:6.75pt 13.5pt 6.75pt 13.5pt;-ms-text-size-adjust: 100%;
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            color:#0099FF'>Meet the Investigators</span></strong></span><span
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            line-height:150%;font-family:"Helvetica",sans-serif;color:#222222'><o:p></o:p></span></span></p>
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            -ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%'>
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             <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:
              yes'>
              <td valign=top style='padding:0cm 13.5pt 6.75pt 13.5pt;
              -ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;
              word-break:break-word'>
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              style='font-size:12.0pt;line-height:150%;font-family:"Arial",sans-serif;
              color:#0099FF'>Timeline</span></strong></span><span
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              line-height:150%;font-family:"Helvetica",sans-serif;color:#757575'><br>
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              src="https://mcusercontent.com/16135105b84da36a23e269059/images/76360c8c-cf92-469e-b245-0af5dd64c7fe.png"
              style='height:3.645in;width:2.708in'><o:p></o:p></span></span></p>
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            -ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;
            word-break:break-word'>
            <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0
             align=left style='max-width:225.0pt;border-collapse:collapse;
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             column;mso-table-left:left;mso-padding-alt:0cm 0cm 0cm 0cm;
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             <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:
              yes'>
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              -ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%'>
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              style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;
              color:#0099FF'>Available now...</span></strong></span><span
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              12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;
              color:#0099FF'><br>
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              href="https://www.youtube.com/watch?v=Kczq92HqCUM&amp;list=PLVmmaARK_GZU779uovke83wezzbQaUZS6"
              target="_blank"><span style='mso-bookmark:_MailOriginal'><span
              style='font-size:12.0pt;line-height:150%;font-family:"Helvetica",sans-serif;
              color:#007C89;text-decoration:none;text-underline:none'><img
              border=0 width=250 height=140 id="_x0000_i1029"
              src="https://mcusercontent.com/16135105b84da36a23e269059/images/a6431f73-9817-42b3-a4b4-cbffbf88ce5d.png"
              style='height:1.458in;width:2.604in'></span></span><span
              style='mso-bookmark:_MailOriginal'></span></a><span
              style='mso-bookmark:_MailOriginal'><span style='font-size:12.0pt;
              line-height:150%;font-family:"Helvetica",sans-serif;color:#757575'><br>
              </span></span><span style='mso-bookmark:_MailOriginal'><em><span
              style='font-size:11.5pt;line-height:150%;font-family:"Helvetica",sans-serif;
              color:black'>Background and Rationale video available now;</span></em></span><span
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              line-height:150%;font-family:"Helvetica",sans-serif;color:#757575'><br>
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              target="_blank"><span style='mso-bookmark:_MailOriginal'><span
              style='font-size:10.5pt;line-height:150%;font-family:"Helvetica",sans-serif;
              color:#007C89'>https://www.tracktrial.org/background-and-rationale/</span></span><span
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